New roles for gluconeogenesis in vertebrates

Gluconeogenesis and glycolysis are the two major opposing metabolic pathways in central carbon metabolism. In vertebrates, biomass generation has been linked primarily to glycolysis, whereas gluconeogenesis has been classically regarded to be limited to specialized gluconeogenic organs. Studies from the recent years, however, show that gluconeogenesis is used by peripheral tissues, immune cells, and cancer cells of different origins to generate...