Biology

Colorectal cancer

Chemoradiotherapy

Prenatal diagnosis

Neoadjuvant therapy

Fetus

Cell-free fetal DNA

Genetics

Internal medicine

Pathological

Chemotherapy

Complete response

Oncology

Medicine

Breast cancer

Cancer

Pregnancy

Annals of Oncology

For locally advanced rectal cancer (LARC) patients who achieved complete clinical response (cCR) after neoadjuvant chemoradiotherapy (nCRT), a “Watch & Wait” (W&W) approach is adopted to improve quality of life. However, W&W may increase the recurrence risk of those who are not pathological complete response (non-pCR). Cell-free DNA (cfDNA) end motifs have been used in cancer detection. But its utility in predicting pCR status has not been reported. In this study, we explored the potential of cfDNA end motif profile in the prediction of pathological response in LARC patients.

451P Utility of circulating free DNA 5’-end motif profile in the prediction of pathological response after neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer