CXCR6+CD4+ T cells promote mortality during Trypanosoma brucei infection
Abstract
Liver macrophages internalize circulating bloodborne parasites. It remains poorly understood how this process affects the fate of the macrophages and T cell responses in the liver. Here, we report that infection by Trypanosoma brucei induced depletion of macrophages in the liver, leading to the repopulation of CXCL16-secreting intrahepatic macrophages, associated with substantial accumulation of CXCR6+CD4+ T cells in the liver. Interestingly,...
Paper Details
Title
CXCR6+CD4+ T cells promote mortality during Trypanosoma brucei infection
Published Date
Oct 6, 2021
Journal
Volume
17
Issue
10
Pages
e1009968 - e1009968
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