A Pregnant Woman With Gross Hematuria and Acute Kidney Injury.

Published on Oct 1, 2021in American Journal of Kidney Diseases8.86
· DOI :10.1053/J.AJKD.2021.05.017
Patrícia Alves17
Estimated H-index: 17
David Navarro30
Estimated H-index: 30
+ 2 AuthorsFernando Nolasco10
Estimated H-index: 10
#1A PefanisH-Index: 1
#2DS WilliamsH-Index: 1
Last. K PaizisH-Index: 1
view all 5 authors...
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides are rare small vessel vasculitides of unknown cause. The pathogenic role of MPO-ANCA in the vasculitides has been supported using various animal models, with B-cells playing a role in the disease pathogenesis. Pregnancy in the presence of an autoimmune disease such as vasculitis is often associated with significant morbidity. Little is known about the outcomes when patients present with de novo vasculitis during pregnancy, and the ...
#1Maria L. Gonzalez Suarez (UMMC: University of Mississippi Medical Center)H-Index: 6
#2Andrea G. Kattah (Mayo Clinic)H-Index: 11
Last. Vesna D. Garovic (Mayo Clinic)H-Index: 54
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As the incidence of chronic kidney disease increases and women pursue pregnancy at more advanced ages, the management of kidney disease in pregnancy has become increasingly relevant to the practicing nephrologist. Women with kidney disorders face several challenges in pregnancy due to increased physiologic demands on the kidney and risk for disease progression, the potential teratogenicity of medications, and the increased risk for complications such as preeclampsia and preterm delivery. Challen...
#1Claire Harris (UBC: University of British Columbia)H-Index: 6
#2Judith G Marin (St. Paul's Hospital)H-Index: 2
Last. Monica Beaulieu (UBC: University of British Columbia)H-Index: 14
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Background The diagnosis of antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is rare in pregnancy but potentially life threatening. There are no randomized controlled trials to guide the management of AAV in pregnancy and fetal safety data remains limited. Rituximab administration, a treatment for AAV, has been reported in pregnant women with reassuring fetal outcomes in the oncology and rheumatology literature; however, no published reports describe its use in AAV.
#1Hamad Bahbahani (MUHC: McGill University Health Centre)H-Index: 1
#2Ahmed AlTurki (MUHC: McGill University Health Centre)H-Index: 10
Last. Mark L. Lipman (JGH: Jewish General Hospital)H-Index: 13
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There is conflicting evidence of benefit versus harm for warfarin anticoagulation in hemodialysis patients with atrial fibrillation. This equipoise may be explained by suboptimal Time in Therapeutic Range (TTR), which correlates well with thromboembolic and bleeding complications. This study aimed to compare nephrologist-led management of warfarin therapy versus that led by specialized anticoagulation clinic. In a retrospective cohort of chronic hemodialysis patients from two institutions (Insti...
#1Belinda Jim (Albert Einstein College of Medicine)H-Index: 16
#2Vesna D. Garovic (Mayo Clinic)H-Index: 54
Summary: Pregnancy-related acute kidney injury (AKI) has declined in incidence in the last three decades, although it remains an important cause of maternal and fetal morbidity and mortality. Pregnancy-related causes of AKI such as preeclampsia, acute fatty liver of pregnancy, HELLP (Hemolysis, Elevated Liver function tests, Low Platelets) syndrome, and the thrombotic microangiopathies (thrombotic thrombocytopenic purpura, atypical hemolytic-uremic syndrome [HUS]) exhibit overlapping features an...
: Granulomatosis with polyangiitis (GPA) is an autoimmune disease which has a variable clinical presentation and usually progresses from a localized to a generalized form over the course of weeks to years. Histopathologically, it is a necrotizing systematic vasculitis that can cause sino-nasal, pulmonary, renal, ocular, and cutaneous manifestations. Diagnostic workup should include serologic, radiologic, endoscopic and histopathological examination. Autoantibody c-ANCA may be used as a marker of...
#1Mariele Gatto (UNIPD: University of Padua)H-Index: 30
#2Luca Iaccarino (UNIPD: University of Padua)H-Index: 50
Last. Andrea Doria (UNIPD: University of Padua)H-Index: 113
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Abstract Primary systemic vasculitis are uncommon diseases that may affect young women in their childbearing age. To date, patients affected with primary systemic vasculitis are often diagnosed and treated earlier than in the past, due to improvement in diagnostic skills and a larger availability of effective drugs. The progressive achievement of a longer life expectancy and a better quality of life have progressively led to an increased number of pregnancies observed during the course of such d...
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