Biotechnology

Organic chemistry

In vivo

Combinatorial chemistry

Kaempferol

Thioether

Stereochemistry

Biology

Medicinal chemistry

Chemistry

In vitro

Myricetin

Antioxidant

Oxadiazole

Quercetin

EC50

Biochemistry

Journal of Agricultural and Food Chemistry

Various 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives were conceived. The title compounds demonstrated striking inhibitory effects against Xac, Psa, and Xoo. EC50 data exhibited that A8 (19.7 μg/mL) had better antibacterial activity against Xoo than myricetin, BT, and TC. Simultaneously, the mechanism of action of A8 had been verified by SEM. The results of anti-tobacco mosaic virus indicated that A9 had the best in vivo antiviral effect compared with ningnanmycin. From the data of MST, it could be seen that A9 (0.003 ± 0.001 μmol/L) exhibited a strong binding capacity, which was far superior to ningnanmycin (2.726 ± 1.301 μmol/L). This study shows that the 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives may become agricultural drugs with great potential.

Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4<i>H</i>-Chromen-4-one Derivatives

Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives