Original paper
NRXN1α+/- is associated with increased excitability in ASD iPSC-derived neurons
Abstract
NRXN1 deletions are identified as one of major rare risk factors for autism spectrum disorder (ASD) and other neurodevelopmental disorders. ASD has 30% co-morbidity with epilepsy, and the latter is associated with excessive neuronal firing. NRXN1 encodes hundreds of presynaptic neuro-adhesion proteins categorized as NRXN1α/β/γ. Previous studies on cultured cells show that the short NRXN1β primarily exerts excitation effect, whereas the long...
Paper Details
Title
NRXN1α+/- is associated with increased excitability in ASD iPSC-derived neurons
Published Date
Sep 15, 2021
Journal
Volume
22
Issue
1
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Notes
History