The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation

Background Microglia cells represent the resident innate immune cells of the retina and are important for retinal development and tissue homeostasis. However, dysfunctional microglia can have a negative impact on the structural and functional integrity of the retina under native and pathological conditions. Methods In this study, we examined interferon-regulatory factor 8 ( Irf8 )–deficient mice to determine the transcriptional profile,...