Extracellular Vesicles and Ciliogenesis as Novel Targets to Stop Opioid Tolerance

SEE CORRESPONDING ARTICLE ON PAGE 575 Astrocyte-Derived Extracellular Vesicle–Mediated Activation of Primary Ciliary Signaling Contributes to the Development of Morphine ToleranceBiological PsychiatryVol. 90Issue 8PreviewMorphine is used extensively in the clinical setting owing to its beneficial effects, such as pain relief; its therapeutic utility is limited because the prolonged use of morphine often results in tolerance and addiction....