Internal medicine

Canagliflozin

Heart failure

Stroke (engine)

Myocardial infarction

Diabetes mellitus

Biology

Endocrinology

Engineering

Cardiology

Intensive care medicine

Paleontology

Type 2 diabetes

Context (archaeology)

Glycemic

Clinical trial

Medicine

Mechanical engineering

International Journal of Molecular Sciences

Selective sodium–glucose cotransporter 2 (SGLT2) inhibitors reduced the risk of hospitalization for heart failure in patients with or without type 2 diabetes (T2DM) in large-scale clinical trials. The exact mechanism of action is currently unclear. The dual SGLT1/2 inhibitor sotagliflozin not only reduced hospitalization for HF in patients with T2DM, but also lowered the risk of myocardial infarction and stroke, suggesting a possible additional benefit related to SGLT1 inhibition. In fact, several preclinical studies suggest that SGLT1 plays an important role in cardiac pathophysiological processes. In this review, our aim is to establish the clinical significance of myocardial SGLT1 inhibition through reviewing basic research studies in the context of SGLT2 inhibitor trials.

Effects of SGLT2 Inhibitors beyond Glycemic Control—Focus on Myocardial SGLT1