Absent or Mild Coronary Calcium Predicts Low-Risk Stress Test Results and Outcomes in Patients Considered for Flecainide Therapy.

Published on Sep 21, 2021in Journal of Cardiovascular Pharmacology and Therapeutics2.457
路 DOI :10.1177/10742484211046671
Thomas Jared Bunch1
Estimated H-index: 1
(UofU: University of Utah)
Sources
Abstract
Background:Flecainide is a useful antiarrhythmic for atrial fibrillation (AF). However, because of ventricular proarrhythmia risk, a history of myocardial infarction (MI) or coronary artery disease...
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References42
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#1Martin B酶dtker Mortensen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 22
#2Omar Dzaye (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 16
Last. Bjarne Linde N酶rgaard (Aarhus University Hospital)H-Index: 54
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Abstract Background Patients with obstructive coronary artery disease (CAD) are at high risk for cardiovascular disease (CVD) events. However, it remains unclear whether the high risk is due to high atherosclerotic disease burden or if presence of stenosis has independent predictive value. Objectives The purpose of this study was to evaluate if obstructive CAD provides predictive value beyond its association with total calcified atherosclerotic plaque burden as assessed by coronary artery calciu...
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#2Ron Blankstein (Brigham and Women's Hospital)H-Index: 78
Last. Michael J. Blaha (Johns Hopkins University)H-Index: 85
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#1Mina K. Chung (Cleveland Clinic)H-Index: 71
#2Marwan M. Refaat (AUB: American University of Beirut)H-Index: 24
Last. Dhanunjaya LakkireddyH-Index: 52
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Highlights 鈥F is a cardiovascular pandemic with a complex pathophysiology and contributes to significant patient morbidity and mortality. 鈥mphasis is on early detection and intervention for stroke prophylaxis and disease progression. 鈥ignificant progress has been made in paroxysmal AF, but better understanding is needed on substrate progression, evolution of non-PV triggers, and a comprehensive approach to multisystem risk factor modification.
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Abstract Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with substantial morbidity and impairment of quality of life. Restoration and maintenance of normal sinus rhythm is a desirable goal for many patients with AF, however, this strategy is limited by the relatively small number of antiarrhythmic drugs (AADs) available for AF rhythm control. Although it is recommended in current medical guidelines as first-line therapy for patients without structural heart di...
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#1Jeffrey L. Anderson (UofU: University of Utah)H-Index: 87
#2Viet T Le (Rocky Mountain University of Health Professions)H-Index: 11
Last. Kirk U. Knowlton (UofU: University of Utah)H-Index: 41
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ABSTRACT Atherosclerotic cardiovascular disease (ASCVD) is the most important cause of morbidity and mortality nationally and internationally. Improving ASCVD risk prediction is a high clinical priority. We sought to determine which of 3 ASCVD risk scores best predicts the need for revascularization and incident major adverse coronary events (MACE) in symptomatic patients at low- intermediate primary ASCVD risk referred for regadenoson-stress positron emission tomography (PET). Risk scores inclu...
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#1Viet T Le (Rocky Mountain University of Health Professions)H-Index: 11
#2Stacey Knight (UofU: University of Utah)H-Index: 22
Last. Kirk U. Knowlton (UofU: University of Utah)H-Index: 41
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Background: Myocardial perfusion imaging, including positron emission tomography/computed tomography (PET/CT), is often used to assess for high-grade coronary artery disease (CAD) requiring revascu...
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#1Martin B酶dtker Mortensen (Aarhus University Hospital)H-Index: 22
#2Valentin Fuster (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 202
Last. Erling Falk (Aarhus University Hospital)H-Index: 71
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Abstract Background Cardiovascular risk increases dramatically with age, leading to nearly universal risk-based statin eligibility in the elderly population. To limit overtreatment, elderly individuals at truly low risk need to be identified. Objectives Discovering 鈥渘egative鈥 risk markers able to identify elderly individuals at low short-term risk for coronary heart disease and cardiovascular disease. Methods In 5,805 BioImage participants (mean age 69 years; median follow-up 2.7 years), the aut...
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#1Michael J. Blaha (Johns Hopkins University)H-Index: 85
#2Ron Blankstein (Brigham and Women's Hospital)H-Index: 78
Last. Khurram NasirH-Index: 77
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#1Daniel B. Mark (Duke University)H-Index: 138
#2Kevin J. Anstrom (Duke University)H-Index: 81
Last. Cabana InvestigatorsH-Index: 2
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Importance Catheter ablation is more effective than drug therapy in restoring sinus rhythm in patients with atrial fibrillation (AF), but its incremental effect on long-term quality of life (QOL) is uncertain. Objective To determine whether catheter ablation is more beneficial than conventional drug therapy for improving QOL in patients with AF. Design, Setting, and Participants An open-label randomized clinical trial of catheter ablation vs drug therapy in 2204 symptomatic patients with AF olde...
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#1Ryan T. Kipp (UW: University of Wisconsin-Madison)H-Index: 7
#2Mariam AskariH-Index: 7
Last. Mintu P. TurakhiaH-Index: 50
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Abstract Objectives In this study the authors investigated effectiveness and safety of an initial treatment strategy with class IC or class III antiarrhythmic drugs (AAD) for newly diagnosed atrial fibrillation (AF) or atrial flutter (AFL). Background There is limited evidence to guide optimal AAD selection for rhythm control in newly diagnosed AF/AFL. Methods Using data from TREAT-AF (The Retrospective Evaluation and Assessment of Therapies in AF), the authors performed a retrospective cohort s...
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