Pathology

Treatment modality

Pathophysiology

Surgery

Intensive care medicine

Radiation injury

Osteoradionecrosis

Radiation therapy

Medicine

Seminars in Plastic Surgery

Radiation therapy is a valuable tool in the treatment of numerous malignancies but, in certain cases, can also causes significant acute and chronic damage to noncancerous neighboring tissues. This review focuses on the pathophysiology of radiation-induced damage and the clinical implications it has for plastic surgeons across breast reconstruction, osteoradionecrosis, radiation-induced skin cancers, and wound healing. The current understanding of treatment modalities presented here include hyperbaric oxygen therapy, autologous fat grafting and stem cells, and pharmaceutical agents.

Radiation-Induced Tissue Damage: Clinical Consequences and Current Treatment Options