Genitourinary system

Pathogenesis

Biology

Endocrinology

Male infertility

Internal medicine

Immunology

Pregnancy

Reproductive system

Genetics

Medicine

Proinflammatory cytokine

Oxidative stress

Infertility

Bioinformatics

Inflammation

Physiology

International Journal of Molecular Sciences

Inflammation is among the core causatives of male infertility. Despite male infertility being a serious global issue, "bits and pieces" of its complex etiopathology still remain missing. During inflammation, levels of proinflammatory mediators in the male reproductive tract are greater than usual. According to epidemiological research, in numerous cases of male infertility, patients suffer from acute or chronic inflammation of the genitourinary tract which typically occurs without symptoms. Inflammatory responses in the male genital system are inextricably linked to oxidative stress (OS). OS is detrimental to male fertility parameters as it causes oxidative damage to reproductive cells and intracellular components. Multifarious male infertility causative factors pave the way for impairing male reproductive functions via the common mechanisms of OS and inflammation, both of which are interlinked pathophysiological processes, and the occurrence of any one of them induces the other. Both processes may be simulta...

Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction