PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the “Cancer Integrin” αvβ6 with Ga-68-Trivehexin

Volume: 49, Issue: 4, Pages: 1136 - 1147
Published: Sep 24, 2021
Abstract
To develop a new probe for the αvβ6-integrin and assess its potential for PET imaging of carcinomas.Ga-68-Trivehexin was synthesized by trimerization of the optimized αvβ6-integrin selective cyclic nonapeptide Tyr2 (sequence: c[YRGDLAYp(NMe)K]) on the TRAP chelator core, followed by automated labeling with Ga-68. The tracer was characterized by ELISA for activities towards integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1, as well as by cell binding...
Paper Details
Title
PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the “Cancer Integrin” αvβ6 with Ga-68-Trivehexin
Published Date
Sep 24, 2021
Volume
49
Issue
4
Pages
1136 - 1147
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