Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity

The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) postulated that patients with stable coronary artery disease (CAD) and moderate or severe ischemia would benefit from revascularization. We investigated the relationship between severity of CAD and ischemia and trial outcomes, overall and by management strategy.In total, 5179 patients with moderate or severe ischemia were randomized...