Review paper
Ligandability of E3 Ligases for Targeted Protein Degradation Applications
Abstract
Targeted protein degradation (TPD) using proteolysis targeting chimeras (PROTACs) and molecular glue degraders has arisen as a powerful therapeutic modality for eliminating disease-causing proteins from cells. PROTACs and molecular glue degraders employ heterobifunctional or monovalent small molecules, respectively, to chemically induce the proximity of target proteins with E3 ubiquitin ligases to ubiquitinate and degrade specific proteins via...
Paper Details
Title
Ligandability of E3 Ligases for Targeted Protein Degradation Applications
Published Date
Sep 2, 2021
Journal
Volume
62
Issue
3
Pages
588 - 600
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