[Heart failure protection by SGLT2 inhibitors in patients with type 2 diabetes mellitus: evidence and possible mechanisms : A systematic review].

Background null Renal sodium-glucose cotransporter‑2 (SGLT2) inhibitors seem to have a cardioprotective effect beyond the antidiabetic effect. The underlying mechanisms are unclear. null Methods null Selective search in PubMed with a focus on heart failure endpoints and possible mechanisms of action. null Results null During treatment with three of the substances analyzed, there were fewer hospitalizations for heart failure compared with...