Original paper
High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies
Abstract
Pegloticase is an enzyme used to reduce serum uric acid levels in patients with chronic, treatment-refractory gout. Clinically, about 40% of patients develop high titers of anti-PEG antibodies (APA) after initial treatment, which in turn quickly eliminate subsequent doses of pegloticase from the systemic circulation and render the treatment ineffective. We previously found that pre-infusion with high MW free PEG (40 kDa) can serve as a decoy to...
Paper Details
Title
High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies
Published Date
Oct 1, 2021
Volume
338
Pages
804 - 812
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Notes
History