Poly(vinyl alcohol)/(hyaluronic acid-g-kappa-carrageenan) hydrogel as antibiotic-releasing wound dressing

The aim of this research was to investigate the potential of ampicillin-loaded hydrogels based on polyvinyl alcohol (PVA), hyaluronic acid (HA) and kappa-carrageenan (K-Carr) as an antibiotic-releasing wound dressing. Firstly, the novel polymers (HA-g-K-Carr) were synthesized by grafting of HA onto K-Carr using 4-dimethylaminopyridine/1-(3-dimethylaminopyl)-3-ethyl-carbodiimide hydrochloride as catalyst system via esterification reaction. The...