FYN, SARS-CoV-2, and IFITM3 in the neurobiology of Alzheimer's disease

(IFITM3) is an innate immune protein that has been identified as a novel γ-secretase (γs) modulator. FYN is a kinase that stabilizes IFITM3 on the membrane, primes APP for amyloidogenic γs processing and mediates tau oligomerization. The purpose of this study is to explore the role of FYN and IFITM3 in AD and COVID-19, expanding on previous research from our group. A 520 gene signature containing FYN and IFITM3 (termed Ia) was extracted from a...