Response to: The Role of Dual Inhibition of EGFR and Vascular EGF(R) in the Treatment of NSCLC With EGFR Mutation.

Published on Sep 1, 2021in Journal of Thoracic Oncology13.357
· DOI :10.1016/J.JTHO.2021.07.013
Hongyun Zhao26
Estimated H-index: 26
(SYSU: Sun Yat-sen University),
Zhonghan Zhang11
Estimated H-index: 11
(SYSU: Sun Yat-sen University),
Li Zhang64
Estimated H-index: 64
(SYSU: Sun Yat-sen University)
#1Hongyun Zhao (SYSU: Sun Yat-sen University)H-Index: 26
view all 25 authors...
Abstract Introduction Blocking vascular endothelial growth factor (VEGF) pathway can enhance the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC). ACTIVE is the first phase III study conducted in China, evaluating apatinib, a VEGFR2 TKI, plus gefitinib as first-line therapy in EGFR-mutant NSCLC. Methods Treatment-naive patients with stage IIIB/IV non-squamous NSCLC, an ECOG PS of 0/1 and EGFR ex19del or ex21L8...
5 CitationsSource
#1Ying ChengH-Index: 29
#2Y. HeH-Index: 6
Last. Suresh S. Ramalingam (Emory University)H-Index: 82
view all 13 authors...
Background In the global FLAURA study, first-line osimertinib, a third-generation irreversible tyrosine kinase inhibitor (TKI) of epidermal growth factor receptor (EGFR), significantly improved progression-free survival (PFS) and overall survival (OS) versus comparator EGFR TKIs in patients with EGFR mutation-positive (EGFRm) advanced non-small-cell lung cancer (NSCLC). Objective The FLAURA China study assessed first-line osimertinib in Chinese patients with EGFRm advanced NSCLC (NCT02296125). M...
6 CitationsSource
#1Tony Mok (CUHK: The Chinese University of Hong Kong)H-Index: 109
#2Ying ChengH-Index: 29
Last. Yi-Long Wu (Academy of Medical Sciences, United Kingdom)H-Index: 94
view all 16 authors...
ARCHER 1050, an ongoing, randomized, open-label, phase III trial of dacomitinib versus gefitinib in newly diagnosed patients with advanced non-small-cell lung cancer (NSCLC) and an EGFR-activating mutation, reported significant improvement in overall survival (OS) with dacomitinib. This paper reports an updated OS analysis of ARCHER 1050 after an extended follow-up. In this multinational, multicenter trial, adults (aged ≥ 18 years or ≥ 20 years in Japan and Korea) with newly diagnosed NSCLC and ...
7 CitationsSource
#1Nobuyuki Yamamoto (Wakayama Medical University)H-Index: 41
#2Takashi SetoH-Index: 52
Last. Masahiro FukuokaH-Index: 74
view all 9 authors...
Abstract Objectives The JO25567 randomized Phase II study demonstrated a statistically significant progression-free survival (PFS) benefit with erlotinib plus bevacizumab compared with erlotinib monotherapy in chemotherapy-naive Japanese patients with epidermal growth factor receptor mutation-positive (EGFR+) non-small-cell lung cancer (NSCLC). Here we present updated PFS and final overall survival (OS) data after a median follow-up of 34.7 months. Materials and methods Patients with stage IIIB/...
11 CitationsSource
#1Makoto Maemondo (Iwate Medical University)H-Index: 38
#2Tatsuro FukuharaH-Index: 17
Last. Kunihiko Kobayashi (Saitama Medical University)H-Index: 32
view all 18 authors...
9506Background: In NEJ026, a phase III trial comparing bevacizumab plus erlotinib (BE) to erlotinib monotherapy (E) for EGFR-mutated non-small-cell lung cancer (NSCLC), we demonstrated the progress...
27 CitationsSource
#1Kazuhiko Nakagawa (Kindai University)H-Index: 97
#2Edward B Garon (UCLA: University of California, Los Angeles)H-Index: 1
Last. Shaker R. DakhilH-Index: 72
view all 116 authors...
Summary Background Dual blockade of the EGFR and VEGF pathways in EGFR-mutated metastatic non-small-cell lung cancer (NSCLC) is supported by preclinical and clinical data, yet the approach is not widely implemented. RELAY assessed erlotinib, an EGFR tyrosine kinase inhibitor (TKI) standard of care, plus ramucirumab, a human IgG1 VEGFR2 antagonist, or placebo in patients with untreated EGFR-mutated metastatic NSCLC. Methods This is a worldwide, double-blind, phase 3 trial done in 100 hospitals, c...
152 CitationsSource
#1Qing Zhou (Academy of Medical Sciences, United Kingdom)H-Index: 29
#2Y-L. Wu (Peking Union Medical College)H-Index: 7
Last. Cheng Huang (Fujian Medical University)H-Index: 15
view all 15 authors...
Abstract Background This study is an open-labeled, randomized, multicenter phase III study to investigate the efficacy and safety of bevacizumab (B) with or without erlotinib (E) in Chinese EGFR-mutated non-small cell lung cancer (NSCLC) patients (NCT02759614). Methods Patients with advanced non-squamous NSCLC harbouring EGFR-mutation were randomly (1:1) assigned to receive either combination with erlotinib (150 mg daily) plus bevacizumab (15 mg/kg iv q3w) or erlotinib (150 mg daily). Random ass...
36 CitationsSource
#1Haruhiro SaitoH-Index: 21
#2Tatsuro FukuharaH-Index: 17
Last. Makoto Maemondo (Iwate Medical University)H-Index: 38
view all 25 authors...
Summary Background Resistance to first-generation or second-generation EGFR tyrosine kinase inhibitor (TKI) monotherapy develops in almost half of patients with EGFR-positive non-small-cell lung cancer (NSCLC) after 1 year of treatment. The JO25567 phase 2 trial comparing erlotinib plus bevacizumab combination therapy with erlotinib monotherapy established the activity and manageable toxicity of erlotinib plus bevacizumab in patients with NSCLC. We did a phase 3 trial to validate the results of ...
194 CitationsSource
#1David PlanchardH-Index: 53
#2Michael BoyerH-Index: 71
Last. Yuichiro OheH-Index: 71
view all 13 authors...
Purpose: In the phase III FLAURA study, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) osimertinib significantly improved progression-free survival (PFS) versus standard-of-care (SoC) EGFR-TKI (gefitinib or erlotinib) in patients with previously untreated EGFR (exon 19 deletion or L858R) mutation-positive advanced non–small cell lung cancer (NSCLC). Interim overall survival (OS) data were encouraging, but not formally statistically significant at current...
33 CitationsSource
#1Martin SchulerH-Index: 65
#2Eng Huat TanH-Index: 47
Last. Keunchil Park (SMC: Samsung Medical Center)H-Index: 77
view all 20 authors...
Purpose In the randomized phase IIb LUX-Lung 7 trial, afatinib significantly improved progression-free survival (PFS) and time-to-treatment failure vs gefitinib in patients with treatment-naive epidermal growth factor receptor mutation-positive non-small cell lung cancer. We report post hoc analyses of tolerability-guided dose adjustment for afatinib and summarize the clinical characteristics of patients who continued afatinib/gefitinib beyond initial radiological progression in LUX-Lung 7.
22 CitationsSource
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