Metformin accelerates wound healing by Akt phosphorylation of gingival fibroblasts in insulin‐resistant prediabetes mice

This study aimed to investigate the effects of metformin on gingival wound healing in insulin-resistant prediabetes.C57BL/6J mice were fed normal diet (ND) or high-fat diet (HFD) for 10 weeks; half of the HFD mice were treated with metformin (HFD+ Met) for the last 2 weeks. Insulin and glucose tolerance tests were performed. The palatal gingiva (2.0 × 0.5 mm) was surgically removed adjacent to the maxillary molars. Post-surgical wound closure...