Donor HLA Class 1 Evolutionary Divergence Is a Major Predictor of Liver Allograft Rejection

The HLA evolutionary divergence (HED), a continuous metric quantifying the peptidic differences between 2 homologous HLA alleles, reflects the breadth of the immunopeptidome presented to T lymphocytes.To assess the potential effect of donor or recipient HED on liver transplant rejection.Retrospective cohort study.Liver transplant units.1154 adults and 113 children who had a liver transplant between 2004 and 2018.Liver biopsies were done 1, 2, 5,...