Internal medicine

Prediabetes

Diabetes mellitus

Endocrinology

Type 2 diabetes

Insulin resistance

Statin

Insulin tolerance test

Insulin

Atorvastatin

Body mass index

Insulin sensitivity

Impaired glucose tolerance

Glucose tolerance test

Medicine

Area under the curve

Arteriosclerosis Thrombosis and Vascular Biology

Statin treatment reduces the risk of atherosclerotic cardiovascular disease but is associated with a modest increased risk of type 2 diabetes, especially in those with insulin resistance or prediabetes. Our objective was to determine the physiological mechanism for the increased type 2 diabetes risk.

Statins Are Associated With Increased Insulin Resistance and Secretion