KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2
Abstract
Epigenetic abnormalities are frequently involved in the initiation and progression of cancers, including acute myeloid leukemia (AML). A subtype of AML, acute promyelocytic leukemia (APL), is mainly driven by a specific oncogenic fusion event of promyelocytic leukemia-RA receptor fusion oncoprotein (PML-RARα). PML-RARα was reported as a transcription repressor through the interaction with nuclear receptor corepressor and histone deacetylase...
Paper Details
Title
KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2
Published Date
Aug 27, 2021
Journal
Volume
5
Issue
17
Pages
3241 - 3253
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Notes
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