Associations between liver PFAS concentrations and plasma extracellular miRNAs in a cohort of adolescents undergoing bariatric surgery

BACKGROUND AND AIM: Perfluoroalkyl substances (PFAS), the “forever chemicals”, accumulate mainly in the liver and have various adverse health effects. Little is known about the mechanistic pathways of PFAS toxicity, but one likely mechanism is alteration of microRNA (miRNA) profiles that regulate post-transcription gene expression. This study aimed to explore relationships between hepatic PFAS concentrations and extracellular miRNAs in...