Th cell transcription factors: Sequence characteristics and expression profiles in Epinephelus coioides after Cryptocaryon irritans infection

Mammalian T cell subset differentiation is strictly controlled by cytokines and transcription factors. T-bet, GATA-3, BCL-6 and Foxp3 are considered the key transcription factors of Th1, Th2, Tfh and Treg cells. Here, we identified the genes and predicted the protein structure of these Th cell transcription factors in the orange-spotted grouper (Epinephelus coioides). The functional domains and 3D-models of grouper T-bet, GATA-3, BCL-6 and Foxp3...