No in vitro activity of cefiderocol against OXA-427-producing Enterobacterales

The prevalence of carbapenem resistance in Enterobacterales is increasing worldwide due to a rapid spread of plasmid-mediated resistance mechanisms. Although new agents have been developed, such as β-lactam/β-lactamase inhibitor combinations, most of these agents have almost no activity against metallo-β-lactamases (MBLs) and limited activity against class D β-lactamases.1 Cefiderocol is a parenteral siderophore cephalosporin with activity...