Original paper
NEI-01-induced arginine deprivation has potent activity against acute myeloid leukemia cells both in vitro and in vivo
Abstract
Recent studies have revealed that targeting amino acid metabolic enzymes is a promising strategy in cancer therapy. Acute myeloid leukemia (AML) downregulates the expression of argininosuccinate synthase (ASS1), a recognized rate-limiting enzyme for arginine synthesis, and yet displays a critical dependence on extracellular arginine for survival and proliferation. This dependence on extracellular arginine, also known as arginine auxotrophy,...
Paper Details
Title
NEI-01-induced arginine deprivation has potent activity against acute myeloid leukemia cells both in vitro and in vivo
Published Date
Aug 25, 2021
Volume
20
Issue
11
Pages
2218 - 2227
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Notes
History