Survival Outcomes for p16-positive Oropharyngeal Squamous Cell Carcinoma Based on Human Papillomavirus Status

Madam — Attempts to de-escalate treatment for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) are ongoing, while a sufficiently low-risk subgroup remains to be identified. Internationally, HPV status is assessed by p16 immunohistochemistry, whereas UK guidance additionally recommends (high-risk) HPV DNA testing. However, controversy remains as to whether p16-positive/HPV-positive and p16-positive/HPV-negative...