Clinical Oncology
Papers 6295
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#1Valérie Fonteyne (Ghent University Hospital)H-Index: 27
#2P. SargosH-Index: 1
External beam radiotherapy (EBRT), as part of a trimodality approach, is an attractive bladder-preserving alternative to radical cystectomy. Several EBRT regimens with different treatment volumes have been described with similar tumour control and, so far, clear recommendations on the optimal radiotherapy regimen and treatment volume are lacking. The current review summarises EBRT literature on dose prescription, fractionation as well as treatment volume in order to guide clinicians in their dai...
1 CitationsSource
#1Brian C. Baumann (UPenn: University of Pennsylvania)H-Index: 16
#2Mohamed ZaghloulH-Index: 12
Last. Vedang MurthyH-Index: 25
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Abstract Local-regional failure for patients with ≥pT3 urothelial carcinoma after radical cystectomy is a significant clinical challenge. Prospective randomised trials have failed to show that chemotherapy reduces the risk of local-regional recurrences. Salvage treatment for local failures is difficult and often unsuccessful. There is promising evidence, particularly from a recent Egyptian National Cancer Institute trial, that radiation therapy plus chemotherapy can significantly reduce local re...
1 CitationsSource
#1V. Kong (Princess Margaret Cancer Centre)H-Index: 1
#2Vibeke N. Hansen (OUH: Odense University Hospital)H-Index: 32
Last. Shaista Hafeez (ICR: Institute of Cancer Research)H-Index: 13
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Technological advancement has facilitated patient-specific radiotherapy in bladder cancer. This has been made possible by developments in image-guided radiotherapy (IGRT). Particularly transformative has been the integration of volumetric imaging into the workflow. The ability to visualise the bladder target using cone beam computed tomography and magnetic resonance imaging initially assisted with determining the magnitude of inter- and intra-fraction target change. It has led to greater confide...
1 CitationsSource
#1Christina UwinsH-Index: 4
Last. Jayanta ChatterjeeH-Index: 23
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Minimally invasive surgery (MIS) has many benefits, in the form of reduced postoperative morbidity, improved recovery and reduced inpatient stay. It is imperative, however, when new techniques are adopted, in the context of treating oncology patients, that the oncological efficacy and safety are established rigorously rather than assumed based on first principles. Here we have attempted to provide a comprehensive review of all the contentious and topical themes surrounding the use of MIS in the ...
#1Belinda A. Campbell (University of Melbourne)H-Index: 16
#2A. Lasocki (Peter MacCallum Cancer Centre)
Last. Greg Wheeler (Peter MacCallum Cancer Centre)H-Index: 14
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Abstract Aims Radiation-induced cavernomas (RIC) are common late toxicities in long-term survivors of malignancy following cerebral irradiation. However, the natural history of RIC is poorly described. We report the first series of long-term surveillance of RIC using modern magnetic resonance imaging (MRI) including highly sensitive susceptibility-weighted imaging (SWI). The aims of this research were to better characterise the natural history of RIC and investigate the utility of MRI-SWI for sc...
#1K. Wakeham (Royal Sussex County Hospital)
#1Katie Wakeham (Glas.: University of Glasgow)H-Index: 12
Last. Duncan C. GilbertH-Index: 21
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Abstract Aims Anal squamous cell carcinomas (ASCC) are strongly associated with human papillomaviruses. Standard of care is chemoradiotherapy at uniform doses with no treatment stratification. Immunohistochemical staining for p16INK4A (p16), a surrogate for human papillomaviruses, is prognostic for outcomes. We investigated this alongside clinical-pathological factors, including tumour infiltrating lymphocyte (TIL) scores. Materials and methods Using an independent, multicentre cohort of 257 ASC...
#1A.M. Brunt (Keele University)H-Index: 12
#1A.M. Brunt (ICR: Institute of Cancer Research)H-Index: 2
Last. John YarnoldH-Index: 71
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Abstract Introduction The phase 3 FAST-Forward trial reported outcomes for 26 and 27 Gy schedules delivered in 5 fractions over 1 week versus 40 Gy in 15 fractions over 3 weeks in 4000 patients. We discuss concerns raised by the radiotherapy community in relation to implementing this schedule. Ipsilateral Breast Tumour Relapse (IBTR) Published estimated 5-year IBTR with 95% CI after 40 Gy in 15 fractions was 2.1% (95% CI 1.4–3.1), 1.7% (1.2–1.6) after 27 Gy and 1.4% (0.2–2.2) after 26 Gy, emphat...
#1L. Wang (Royal Surrey County Hospital)
#1S. Brown (Gloucestershire Hospitals NHS Foundation Trust)
#2M. Beasley (Leeds Teaching Hospitals NHS Trust)H-Index: 1
Last. M. van Herk (University of Manchester)H-Index: 31
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Abstract Aims So far, the impact of intra-thoracic anatomical changes (ITACs) on patients treated with stereotactic ablative radiotherapy (SABR) for early-stage non-small cell lung cancer is unknown. Studying these is important, as ITACs have the potential to impact the workflow and reduce treatment quality. The aim of this study was to assess and categorise ITACs, as detected on cone beam computed tomography scans (CBCT), and their subsequent impact upon treatment in lung cancer patients treate...
#1P Lewis (University Hospitals Bristol NHS Foundation Trust)H-Index: 1
#2A.M. Brunt (Keele University)H-Index: 12
Last. T. Roques (Royal College of Radiologists)H-Index: 1
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1 CitationsSource
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