Spatially organized multicellular immune hubs in human colorectal cancer
Abstract
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal tumors and adjacent normal tissues of 28 MMRp and 34 MMRd individuals. Analysis of 88 cell subsets and their 204 associated gene expression programs...
Paper Details
Title
Spatially organized multicellular immune hubs in human colorectal cancer
Published Date
Sep 1, 2021
Journal
Volume
184
Issue
18
Pages
4734 - 4752.e20
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