GPX1

Starvation

Cell biology

Cystine

Biology

GPX4

Endocrinology

Biochemistry

Glutathione

Glutathione peroxidase

Cysteine

Enzyme

Chemistry

Nature Communications

The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis