Chemotherapy toxicity and activity in patients with pancreatic ductal adenocarcinoma and germline BRCA1-2 pathogenic variants (gBRCA1-2pv): a multicenter survey

Giulia Orsi; M. Di Marco; Alessandro Cavaliere; Monica Niger; Silvia Bozzarelli; Guido Giordano; Silvia Noventa; I.G. Rapposelli; Ingrid Garajová; Giampaolo Tortora; Michele Reni

doi:https://doi.org/10.1016/j.esmoop.2021.100238

doi.org/10.1016/j.esmoop.2021.100238

Chemotherapy toxicity and activity in patients with pancreatic ductal adenocarcinoma and germline BRCA1-2 pathogenic variants (gBRCA1-2pv): a multicenter survey

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..., Michele Reni

59

ESMO Open7.30

Volume: 6, Issue: 5, Pages: 100238 - 100238

Published: Oct 1, 2021

Abstract

Germline BRCA1-2 pathogenic variants (gBRCA1-2pv)-related pancreatic ductal adenocarcinoma (PDAC) showed increased sensitivity to DNA cross-linking agents. This study aimed at exploring safety profile, dose intensity, and activity of different chemotherapy regimens in this setting.gBRCA1-2pv PDAC patients of any age and clinical tumor stage who completed a first course of chemotherapy were eligible. A descriptive analysis of chemotherapy...

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Paper Details

Title

Chemotherapy toxicity and activity in patients with pancreatic ductal adenocarcinoma and germline BRCA1-2 pathogenic variants (gBRCA1-2pv): a multicenter survey

DOI

doi.org/10.1016/j.esmoop.2021.100238

Published Date

Oct 1, 2021

Journal

ESMO Open

Volume

6

Issue

5

Pages

100238 - 100238

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