Phenotype

DNA damage

Genome instability

Biology

Gene

Cancer

Chromosome instability

Paclitaxel

Aneuploidy

Chromosome

Cancer research

Genetics

Cancer cell

Developmental Cell

Chromosomal instability (CIN) is a hallmark of cancer and is frequently found to correlate with aggressive disease. However, the role of CIN in driving tumor progression is poorly understood. Here, Lukow et al. demonstrate a role for CIN in promoting therapeutic resistance through the acquisition of specific aneuploidies.

Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies