Original paper
Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy
Abstract
Chemotherapy with cisplatin becomes limiting due to toxicity and secondary malignancies. In principle, therapeutics could be improved by targeting translesion synthesis (TLS) polymerases (Pols) that promote replication through intrastrand cross-links, the major cisplatin-induced DNA adduct. However, to specifically target malignancies with minimal adverse effects on normal cells, a good understanding of TLS mechanisms in normal versus cancer...
Paper Details
Title
Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy
Published Date
Aug 12, 2021
Journal
Volume
35
Issue
17-18
Pages
1256 - 1270
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Notes
History