STAT3 maintains skin barrier integrity by modulating SPINK5 and KLK5 expression in keratinocytes
Abstract
Skin barrier dysfunction induces skin inflammation. Signal transducer and activator of transcription 3 (STAT3) is known to be involved in Th17-mediated immune responses and barrier integrity in the cornea and intestine; however, its role in the skin barrier remains largely unknown. In this study, we elucidated the potential role of STAT3 in the skin barrier and its effect on kallikrein-related peptidase 5 (KLK5) and serine protease inhibitor...
Paper Details
Title
STAT3 maintains skin barrier integrity by modulating SPINK5 and KLK5 expression in keratinocytes
Published Date
Aug 20, 2021
Journal
Volume
31
Issue
2
Pages
223 - 232
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History