De-intensification in older people with type 2 diabetes: why, when and for whom?

As a result of the dwindling physiological reserves in ageing, medication pharmacokinetics, pharmacodynamics, efficacy, and side-effects differ substantially among people in older age groups compared with those in younger age groups. This decline in physiological capacity worsens gradually until the end of life. Most guidelines on type 2 diabetes treatment are based on clinical trials done in carefully selected younger patients, and therefore...