Pericoronary and periaortic adipose tissue density are associated with inflammatory disease activity in Takayasu arteritis and atherosclerosis

Published on Sep 8, 2021
· DOI :10.1093/EHJOPEN/OEAB019
Christopher Wall2
Estimated H-index: 2
(University of Cambridge),
Yuan Huang14
Estimated H-index: 14
(University of Cambridge)
+ 24 AuthorsLuigi Aloj2
Estimated H-index: 2
(University of Cambridge)
#1Andrew Lin (Monash University)H-Index: 8
#2Nitesh Nerlekar (Monash University)H-Index: 17
Last. Dennis T.L. Wong (Monash University)H-Index: 19
view all 8 authors...
AIMS Vascular inflammation inhibits local adipogenesis in pericoronary adipose tissue (PCAT) and this can be detected on coronary computed tomography angiography (CCTA) as an increase in CT attenuation of PCAT surrounding the proximal right coronary artery (RCA). In this cross-sectional study, we assessed the utility of PCAT CT attenuation as an imaging biomarker of coronary inflammation in distinguishing different stages of coronary artery disease (CAD). METHODS AND RESULTS Sixty patients with ...
2 CitationsSource
Coronary computed tomography angiography (CTA) is a first-line investigation in suspected coronary artery disease ([1][1],[2][2]). Further to the detection of luminal stenosis, coronary CTA can characterize distinct high-risk plaque (HRP) features associated with an increased risk of adverse events
14 CitationsSource
#1Jason M. Tarkin (University of Cambridge)H-Index: 15
#2Christopher Wall (University of Cambridge)H-Index: 2
Last. Justin C. Mason (NIH: National Institutes of Health)H-Index: 62
view all 11 authors...
6 CitationsSource
#1Evangelos Tzolos (Edin.: University of Edinburgh)H-Index: 6
#2Priscilla McElhinney (Cedars-Sinai Medical Center)H-Index: 6
Last. Damini Dey (Cedars-Sinai Medical Center)H-Index: 58
view all 9 authors...
Abstract Background High pericoronary adipose tissue (PCAT) attenuation and non-calcified plaque burden (NCP) measured from coronary CT angiography (CTA) have been implicated in future cardiac events. We aimed to evaluate the interobserver and intraobserver repeatability of PCAT attenuation and NCP burden measurement from CTA, in a sub-study of the prospective SCOT-HEART trial. Methods Fifty consecutive CTAs from participants of the CT arm of the prospective SCOT-HEART trial were included. Two e...
9 CitationsSource
#1Evangelos Oikonomou (John Radcliffe Hospital)H-Index: 32
#2Michelle C. Williams (BHF: British Heart Foundation)H-Index: 28
Last. Charalambos AntoniadesH-Index: 74
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Background Coronary inflammation induces dynamic changes in the balance between water and lipid content in perivascular adipose tissue (PVAT), as captured by perivascular Fat Attenuation Index (FAI) in standard coronary CT angiography (CCTA). However, inflammation is not the only process involved in atherogenesis and we hypothesized that additional radiomic signatures of adverse fibrotic and microvascular PVAT remodelling, may further improve cardiac risk prediction.
89 CitationsSource
#1Youssef A. Elnabawi (NIH: National Institutes of Health)H-Index: 7
#2Evangelos Oikonomou (University of Oxford)H-Index: 32
Last. Nehal N. Mehta (NIH: National Institutes of Health)H-Index: 62
view all 20 authors...
Importance Psoriasis is a chronic inflammatory skin disease associated with increased coronary plaque burden and cardiovascular events. Biologic therapy for psoriasis has been found to be favorably associated with luminal coronary plaque, but it is unclear whether these associations are attributable to direct anti-inflammatory effects on the coronary arteries. Objective To investigate the association of biologic therapy with coronary inflammation in patients with psoriasis using the perivascular...
56 CitationsSource
#1Charalambos Antoniades (University of Oxford)H-Index: 74
#2Alexios S. Antonopoulos (University of Oxford)H-Index: 28
Last. John E. DeanfieldH-Index: 131
view all 3 authors...
: Targeting residual cardiovascular risk in primary and secondary prevention, would allow deployment of novel therapeutic agents, facilitating precision medicine. For example, lowering vascular inflammation is a promising strategy to reduce the residual inflammatory cardiovascular risk in patients already receiving optimal medical therapy, but prescribing novel anti-inflammatory treatments will be problematic due to the lack of specific companion diagnostic tests, to guide their targeted use in ...
35 CitationsSource
#1Markus Goeller (FAU: University of Erlangen-Nuremberg)H-Index: 11
#2Balaji Tamarappoo (Cedars-Sinai Medical Center)H-Index: 24
Last. Damini Dey (Cedars-Sinai Medical Center)H-Index: 58
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AIMS: Increased attenuation of pericoronary adipose tissue (PCAT) around the proximal right coronary artery (RCA) from coronary computed tomography angiography (CTA) has been shown to be associated with coronary inflammation and improved prediction of cardiac death over plaque features. Our aim was to investigate whether PCAT CT attenuation is related to progression of coronary plaque burden. METHODS AND RESULTS: We analysed CTA studies of 111 stable patients (age 59.2 ± 9.8 years, 77% male) who...
44 CitationsSource
#1Jacek KwiecinskiH-Index: 16
#2Damini Dey (Cedars-Sinai Medical Center)H-Index: 58
Last. Daniel S. Berman (Cedars-Sinai Medical Center)H-Index: 160
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Abstract Objectives This study aimed to assess the association between increased lesion peri-coronary adipose tissue (PCAT) density and coronary 18F-sodium fluoride (18F-NaF) uptake on positron emission tomography (PET) in stable patients with high-risk coronary plaques (HRPs) shown on coronary computed tomography angiography (CTA). Background Coronary 18F-NaF uptake reflects the rate of calcification of coronary atherosclerotic plaque. Increased PCAT density is associated with vascular inflamma...
58 CitationsSource
#1Jacek Kwiecinski (Edin.: University of Edinburgh)H-Index: 16
#2Philip D. Adamson (Edin.: University of Edinburgh)H-Index: 26
Last. Piotr J. Slomka (Cedars-Sinai Medical Center)H-Index: 75
view all 15 authors...
Background: We assessed the feasibility of utilizing previously acquired computed tomography angiography (CTA) with subsequent positron-emission tomography (PET)-only scan for the quantitative eval...
22 CitationsSource
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