Review paper
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
Abstract
The kynurenine (KYN) pathway (KP) of tryptophan (TRP) metabolism is dysregulated in inflammation-driven pathologies including oncological and brain diseases [e.g., multiple sclerosis (MS), depression] and thus is a promising therapeutic target. Both pathological and compensatory mechanisms underlie disease-associated KP activation. There is growing evidence for bioenergetic roles of certain KP metabolites such as kynurenic acid (KA), or...
Paper Details
Title
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
Published Date
Oct 1, 2021
Journal
Volume
27
Issue
10
Pages
946 - 954
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