Sixth-generation (6G) wireless networks are envisioned to provide global coverage for the intelligent digital society of the near future, ranging from traditional terrestrial to non-terrestri-al networks, where reliable communications in high-mobility scenarios at high carrier frequencies would play a vital role. In such scenarios, the conventional orthogonal frequency division multiplexing (OFDM) modulation, that has been widely used in both the fourth-generation (4G) and the emerging fifth-generation (5G) cellular systems as well as in WiFi networks, is vulnerable to severe Doppler spread. In this context, this article aims to introduce a recently proposed two-dimension-al modulation scheme referred to as orthogonal time-frequency space (OTFS) modulation, which conveniently accommodates the channel dynamics via modulating information in the delay-Doppler domain. This article provides an easy-reading overview of OTFS, highlighting its underlying motivation and specific features. The critical challenges of OTFS and our preliminary results are presented. We also discuss a range of promising research opportunities and potential applications of OTFS in 6G wireless networks.