Genome

Gene dosage

Chromosome instability

Cancer research

DNA damage

Genome instability

Biology

Gene

Mitosis

Copy-number variation

Cancer

Gene expression

Aneuploidy

Chromosome

Karyotype

Genetics

Developmental Cell

Ippolito et al. show that induction of chromosome mis-segregation leads to increased karyotypic heterogeneity that could be exploited by cancer cells to survive during chemotherapy. Chemoresistant cells harbor recurrent karyotypes, which impose gene copy-number changes and consequent altered expression of specific proteins crucial for chemoresistance.

Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy