Autocrine FGF21 signalling promotes beiging.

Published on Sep 1, 2021in Nature Reviews Endocrinology28.8
· DOI :10.1038/S41574-021-00541-X
Anna Kriebs4
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#1Mohammad Abu-Odeh (UCSD: University of California, San Diego)H-Index: 1
#2Yuan Zhang (UTSW: University of Texas Southwestern Medical Center)H-Index: 16
Last. Xin Zhou (UCSD: University of California, San Diego)H-Index: 11
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The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion of the FGF21 co-receptor β-Klotho renders mice unresponsive to β-adrenergic stimulation. In contrast, mice with liver-specific ablation of FGF21, which eliminates circulating FGF21, remain sensitive to β-adrenergic browning of iWAT. Concordantly, transgenic overexpressi...
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