Red blood cells contain enzymatically active GPx4 whose abundance anticorrelates with hemolysis during blood bank storage
Abstract
The antioxidant function of the phospholipid hydroperoxide glutathione peroxidase (GPx4) is vital for the homeostasis of many cell types, from neoplastic cells to normal erythroid precursors. However, some functional proteins in erythroid precursors are lost during the development of red blood cells (RBCs); whether GPx4 is maintained as an active enzyme in mature RBCs has remained unclear. Our meta-analyses of existing RBC proteomics and...
Paper Details
Title
Red blood cells contain enzymatically active GPx4 whose abundance anticorrelates with hemolysis during blood bank storage
Published Date
Oct 1, 2021
Journal
Volume
46
Pages
102073 - 102073
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