Aldose Reductase: a cause and a potential target for the treatment of diabetic complications

Volume: 44, Issue: 7, Pages: 655 - 667
Published: Jul 1, 2021
Abstract
Diabetes mellitus, a disorder of metabolism, results in the elevation of glucose level in the blood. In this hyperglycaemic condition, aldose reductase overexpresses and leads to further complications of diabetes through the polyol pathway. Glucose metabolism-related disorders are the accumulation of sorbitol, overproduction of NADH and fructose, reduction in NAD+, and excessive NADPH usage, leading to diabetic pathogenesis and its complications...
Paper Details
Title
Aldose Reductase: a cause and a potential target for the treatment of diabetic complications
Published Date
Jul 1, 2021
Volume
44
Issue
7
Pages
655 - 667
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