Synthesis of α,ω-Diketodiesters from Betulin
Abstract
A new synthesis of 3-oxo-28-hydroxylup-20(29)-ene from the available natural triterpenoid betulin was developed. α,ω-Diketodiesters were prepared for the first time by different methods from 3-oxo-28-hydroxylup-20(29)-ene and a series of natural dicarboxylic acids. Steglich reaction conditions gave the highest yields. One of the synthesized α,ω-diketodiesters was moderately active in vitro against A-549 lung...
Paper Details
Title
Synthesis of α,ω-Diketodiesters from Betulin
Published Date
Jul 1, 2021
Volume
57
Issue
4
Pages
706 - 711
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