A Novel ZIP4-HDAC4-VEGFA Axis in High-Grade Serous Ovarian Cancer
Abstract
We have recently identified ZIP4 as a novel cancer stem cell (CSC) marker in high-grade serous ovarian cancer (HGSOC). While it converts drug-resistance to cisplatin (CDDP), we unexpectedly found that ZIP4 induced sensitization of HGSOC cells to histone deacetylase inhibitors (HDACis). Mechanistically, ZIP4 selectively upregulated HDAC IIa HDACs, with little or no effect on HDACs in other classes. HDAC4 knockdown (KD) and LMK-235 inhibited...
Paper Details
Title
A Novel ZIP4-HDAC4-VEGFA Axis in High-Grade Serous Ovarian Cancer
Published Date
Jul 29, 2021
Journal
Volume
13
Issue
15
Pages
3821 - 3821
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