The Diverse Functions of Small Heat Shock Proteins in the Proteostasis Network
Abstract
The protein quality control (PQC) system maintains protein homeostasis by counteracting the accumulation of misfolded protein conformers. Substrate degradation and refolding activities executed by ATP-dependent proteases and chaperones constitute major strategies of the proteostasis network. Small heat shock proteins represent ATP-independent chaperones that bind to misfolded proteins, preventing their uncontrolled aggregation. sHsps share the...
Paper Details
Title
The Diverse Functions of Small Heat Shock Proteins in the Proteostasis Network
Published Date
Jan 1, 2022
Journal
Volume
434
Issue
1
Pages
167157 - 167157
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