Autophagy inhibition in breast cancer cells induces ROS-mediated MIF expression and M1 macrophage polarization

Volume: 86, Pages: 110075 - 110075
Published: Oct 1, 2021
Abstract
Autophagy can function as a survival mechanism for cancer cells and therefore, its inhibition is currently being explored as a therapy for different cancer types. For breast cancer, triple negative breast cancer (TNBC) is the subtype most sensitive to the inhibition of autophagy; but its inhibition has also been shown to promote ROS-dependent secretion of macrophage migration inhibitory factor (MIF), a pro-tumorigenic cytokine. In this work, we...
Paper Details
Title
Autophagy inhibition in breast cancer cells induces ROS-mediated MIF expression and M1 macrophage polarization
Published Date
Oct 1, 2021
Volume
86
Pages
110075 - 110075
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