Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development

Volume: 35, Issue: 9, Pages: 718 - 733
Published: Sep 20, 2021
Abstract
Significance: Acetaminophen (APAP) is one of the quantitively most consumed drugs worldwide. Although safe at therapeutic doses, intentional or unintentional overdosing occurs frequently causing severe liver injury and even liver failure. In the United States, 50% of all acute liver failure cases are caused by APAP overdose. However, only one antidote with a limited therapeutic window, N-acetylcysteine, is clinically approved. Thus, more...
Paper Details
Title
Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development
Published Date
Sep 20, 2021
Volume
35
Issue
9
Pages
718 - 733
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