Antioxidants & Redox Signaling
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#1Xiangyu Teng (UF: University of Florida)H-Index: 5
#2Josephine Brown (UF: University of Florida)H-Index: 3
Last. Laurence Morel (UF: University of Florida)H-Index: 58
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SIGNIFICANCE Metformin has been proposed as a treatment for systemic lupus erythematosus (SLE). The primary target of metformin, the electron transport chain complex I in the mitochondria, is associated with redox homeostasis in immune cells, which plays a critical role in the pathogenesis of autoimmune diseases. This review addresses the evidence and knowledge gaps on whether a beneficial effect of metformin in lupus may be due to a restoration of a balanced redox state. Recent Advances: Clinic...
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#1Christopher Spankovich (UMMC: University of Mississippi Medical Center)H-Index: 14
#2Bradley J. Walters (UMMC: University of Mississippi Medical Center)
Significance null Sensorineural hearing loss has significant implications for quality of life and risk for co-morbidities such as cognitive decline. Noise and ototoxic drugs represent two common risk factors for acquired hearing loss that are pontentially preventable. Recent Advances: Numerous otoprotection strategies have been postulated over the past four decades with primary targets of upstream redox pathways. More recently, the application of mild therapeutic hypothermia has shown promise fo...
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#1Sandeep Subrahmanian (OMRF: Oklahoma Medical Research Foundation)
#2Rohan Varshney (OMRF: Oklahoma Medical Research Foundation)H-Index: 14
Last. Jasimuddin Ahamed (OMRF: Oklahoma Medical Research Foundation)H-Index: 1
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Objective null Aortic stenosis (AS) is characterized by narrowing of aortic valve opening, resulting in peak blood flow velocity that induces high wall shear stress (WSS) across the valve. Severe AS leads to heart failure and death. There is no treatment available for AS other than valve replacement. Platelet-derived TGF-β1 partially contributes to AS progression in mice, and WSS is a potent activator of latent TGF-β1. N-acetylcysteine (NAC) inhibits WSS-induced TGF-β1 activation in vitro. We hy...
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#1Bindu D. Paul (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 29
Significance: Ergothioneine (ET) is an unusual sulfur containing amino acid derived from histidine, acquired predominantly from the diet. Its depletion is associated with deleterious consequences i...
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#2Thibaut DuparcH-Index: 17
Last. Laurent O. Martinez (French Institute of Health and Medical Research)H-Index: 24
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Significance The mitochondrial oxidative phosphorylation (OXPHOS) system, comprising the electron transport chain and ATP synthase, generates membrane potential, drives ATP synthesis, governs energy metabolism, and maintains redox balance. OXPHOS dysfunction is associated with a plethora of diseases ranging from rare inherited disorders to common conditions including diabetes, cancer, neurodegenerative diseases, as well as aging. There has been great interest in studying regulators of OXPHOS. Am...
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#1Arjun Sharma (BU: Boston University)H-Index: 6
#2Konstantinos Kontodimas (BU: Boston University)
Last. Markus Bosmann (BU: Boston University)H-Index: 24
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Significance: It is estimated that close to 50 million cases of sepsis result in over 11 million annual fatalities worldwide. The pathognomonic feature of sepsis is a dysregulated inflammatory response arising from viral, bacterial, or fungal infections. Immune recognition of pathogen-associated molecular patterns is a hallmark of the host immune defense to combat microbes and to prevent the progression to sepsis. Mitochondrial antiviral signaling protein (MAVS) is a ubiquitous adaptor protein l...
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#1Samuel David (McGill University)H-Index: 66
#2Priya Jhelum (MUHC: McGill University Health Centre)H-Index: 6
Last. Antje Kroner (MCW: Medical College of Wisconsin)H-Index: 28
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Significance: Iron accumulation occurs in the CNS in a variety of neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis, Parkinson’s disease, and others. Iron is a re...
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#1Melis Sahinoz (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Fernando Elijovich (VUMC: Vanderbilt University Medical Center)H-Index: 20
Last. Annet Kirabo (VUMC: Vanderbilt University Medical Center)H-Index: 18
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Significance: Salt-sensitivity of blood pressure (SSBP) is an independent risk factor for mortality and morbidity due to cardiovascular disease, and disproportionately affects blacks and women. Sev...
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#1Lincon Felipe Lima-Silva (USP: University of São Paulo)
#2Jennifer Lee (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 19
Last. Pedro Capra Vieira (State University of Campinas)
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Significance: Immunometabolic regulation of macrophages has been the target of many researchers. Here we review the contribution of solute carriers (SLC) in regulating macrophage metabolism. We als...
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#1Xiaoqing Zheng (University of Pittsburgh)H-Index: 1
#2Amr H. Sawalha (University of Pittsburgh)H-Index: 53
Significance: Epigenetic dysregulation plays an important role in the pathogenesis and development of autoimmune diseases. Oxidative stress is associated with autoimmunity and is also known to alte...
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Oxidative stress
Reactive oxygen species
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